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Delivery of Therapeutic Proteins Using Electrospun Fibers—Recent Developments and Current Challenges
Author(s) -
Seif Salem,
Planz Viktoria,
Windbergs Maike
Publication year - 2017
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201700077
Subject(s) - current (fluid) , chemistry , nanotechnology , computational biology , biology , engineering , materials science , electrical engineering
Proteins play a vital role within the human body by regulating various functions and even serving as structural constituent of many body parts. In this context, protein‐based therapeutics have attracted a lot of attention in the last few decades as potential treatment of different diseases. Due to the steadily increasing interest in protein‐based therapeutics, different dosage forms were investigated for delivering such complex macromolecules to the human body. Here, electrospun fibers hold a great potential for embedding proteins without structural damage and for controlled release of the protein for therapeutic applications. This review provides a comprehensive overview of the current state of protein‐based carrier systems using electrospun fibers, with special emphasis on discussing their potential and key challenges in developing such therapeutic strategies, along with a prospective view of anticipated future directions.