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Benzimidazole Scaffold as Anticancer Agent: Synthetic Approaches and Structure–Activity Relationship
Author(s) -
Shrivastava Neelima,
Naim Mohd. Javed,
Alam Md. Jahangir,
Nawaz Farah,
Ahmed Shujauddin,
Alam Ozair
Publication year - 2017
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201700040
Subject(s) - benzimidazole , pharmacophore , chemistry , combinatorial chemistry , imidazole , stereochemistry , organic chemistry
Cancer, also known as malignant neoplasm, is a dreadful disease which involves abnormal cell growth having the potential to invade or spread to other parts of the body. Benzimidazole is an organic compound that is heterocyclic and aromatic in nature. It is a bicyclic compound formed by the fusion of the benzene and imidazole ring systems. It is an important pharmacophore and a privileged structure in medicinal chemistry. According to the World Health Organisation (2015 survey), one in six deaths is due to cancer around the globe, accounting for 8.8 million deaths of which 70% of the cases were from low‐ and middle‐income countries. In the efforts to develop suitable anticancer drugs, medicinal chemists have focussed on benzimidazole derivatives. This review article covers the current development of benzimidazole‐based anticancer agents along with the synthetic approaches and structure–activity relationships (SAR).