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Synthesis, Characterization, and Biological Evaluation of Some Novel Quinoxaline Derivatives as Antiviral Agents
Author(s) -
ElZahabi Heba S. A.
Publication year - 2017
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201700028
Subject(s) - quinoxaline , chemistry , selectivity , cytotoxicity , ganciclovir , stereochemistry , chemical synthesis , biological activity , human cytomegalovirus , in vitro , organic chemistry , biochemistry , gene , catalysis
Ethyl (6,7‐dimethyl‐2‐oxo‐3,4‐dihydroquinoxalin‐3‐yl)acetate and ethyl (6‐methyl‐2‐oxo‐3,4‐dihydroquinoxalin‐3‐yl)acetate ( 1a , b ), 3‐methylquinoxalin‐2(1 H )‐one ( 4 ) and 1,4‐dihydroquinoxaline‐2,3‐dione ( 11 ) were the starting precursors for nine novel quinoxaline compounds, 3a , 6 , 10 , 13 , 15 , 16 , 17 , 18 , and 20 , via adopting different nucleophilic reactions. The synthesized compounds were tested for their antiviral activity against HCV, HBV, HSV‐1, and HCMV. Concomitantly, their safety profile was investigated as well as their selectivity against the viral strains. The Virology Unit at the University of Alabama recorded that two compounds, i.e., 1a and 20 , exhibited highly potent activity against HCMV with lower IC 50 values (<0.05 μM) compared to ganciclovir (IC 50 = 0.59 μM). Compounds 1a and 20 also exhibited low cytotoxicity together with a high selectivity index.