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Synthesis of Novel Pyrazolines, Their Boron–Fluorine Complexes, and Investigation of Antibacterial, Antioxidant, and Enzyme Inhibition Activities
Author(s) -
Kahriman Nuran,
Haşimoğlu Zeynep,
Serdaroğlu Vildan,
Beriş Fatih Şaban,
Barut Burak,
Yaylı Nurettin
Publication year - 2017
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201600285
Subject(s) - pyrazoline , chemistry , antioxidant , boron , enzyme , antibacterial activity , acetylcholinesterase , nuclear chemistry , tyrosinase , fluorine , organic chemistry , combinatorial chemistry , bacteria , genetics , biology
New 3,5‐disubstituted‐2‐pyrazoline derivatives ( 4–6 ), their boron‐fluorine complexes (boron (3‐(2′‐aminophenyl),5‐(2′‐/3′‐/4′‐pyridyl)pyrazoline, BOAPPY) ( 7–9 ) and boron 1,2′‐diazaflavone complex (BODAF) ( 11 ) were synthesized starting from azachalcones ( 1–3 ) to diazaflavone ( 10 ), respectively. Biological evaluation of compounds 4–9 and 11 showed remarkable antioxidant, antibacterial, and acetylcholinesterase and tyrosinase enzyme inhibition activities. All newly synthesized compounds 4–9 and 11 showed respectable antibacterial effect with minimum inhibitory concentrations in the range of 4.7–150 μg/mL.