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Synthesis, Molecular Mechanism and Pharmacokinetic Studies of New Epoxy Lignan‐Based Derivatives
Author(s) -
Rifai Yusnita,
Tani Harold B.,
Nur Muhammad,
Aswad Muhammad,
Lallo Subehan,
Wahyudin Elly
Publication year - 2016
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201600069
Subject(s) - lignan , methylenedioxy , chemistry , pharmacokinetics , demethylation , sesamin , pharmacology , stereochemistry , biochemistry , organic chemistry , gene expression , gene , medicine , alkyl , halogen , dna methylation , food science
The oxidative demethylation procedure for a new epoxy lignan isolated from Piper nigrum was applied to the synthesis of 3’‐methoxy‐3”,4”‐(methylenedioxy)‐2,5‐epoxylignan‐4’‐ol‐6’‐one. This compound inhibited the mRNA expression of the protein patched homolog (Ptch) in human pancreatic cancer cells (PANC1) and therefore might be valuable as a probe for tumor‐related disease. The pharmacokinetic profile of 3'‐methoxy‐3”,4”‐(methylenedioxy)‐2,5‐epoxylignan‐4'‐ol‐6'‐one was rapidly determined using ultra‐fast liquid chromatography. The compound was rapidly absorbed in blood.