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Effects of Curcuminoid Pyrazoles on Cancer Cells and on the Expression of Telomerase Related Genes
Author(s) -
MartíCentelles Rosa,
Falomir Eva,
Carda Miguel,
Nieto Carla I.,
Cornago M. Pilar,
Claramunt Rosa M.
Publication year - 2016
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201600067
Subject(s) - curcuminoid , telomerase , hela , curcumin , telomerase reverse transcriptase , cell culture , chemistry , cytotoxicity , downregulation and upregulation , gene , hek 293 cells , microbiology and biotechnology , cell , cancer research , biology , biochemistry , genetics , in vitro
A group of 13 curcuminoid pyrazoles was investigated for their cytotoxicity on three tumoral cell lines (HT‐29, MCF‐7, and HeLa) and one non‐tumoral human cell line (HEK‐293). The values obtained were compared with those of curcumin. A subset of selected derivatives was also studied for their ability to downregulate expression of the hTERT and c‐Myc genes, which are both involved in telomerase activity.