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Toolbox for Antibiotics Discovery from Microorganisms
Author(s) -
Fisch Katja M.,
Schäberle Till F.
Publication year - 2016
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201600064
Subject(s) - drug discovery , toolbox , computational biology , genome , heterologous expression , biology , microbiology and biotechnology , chemistry , biochemical engineering , gene , bioinformatics , genetics , computer science , recombinant dna , engineering , programming language
Microorganisms produce a vast array of biologically active metabolites. Such compounds are applied by humans to positively influence their health and, therefore, natural products serve as drug leads for pharmaceutical and medicinal chemistry. In this minireview, tools for the discovery and the production of potential drug leads are explained. A snapshot is provided, starting from the isolation of new producer strains, across genomic mining of (meta)genomes to identify biosynthetic gene clusters corresponding to natural products, toward heterologous expression to produce potential drug leads.