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Biological Evaluation of Ferrocenyl Olefins: Cancer Cell Growth Inhibition, ROS Production, and Apoptosis Activity
Author(s) -
Sun Aijing,
Lin Junsheng,
Pi Chao,
Xu Ruian,
Cui Xiuling
Publication year - 2016
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201500314
Subject(s) - umbilical vein , apoptosis , chemistry , cell growth , a549 cell , reactive oxygen species , cancer cell , cell cycle , cell cycle checkpoint , cell culture , mtt assay , human umbilical vein endothelial cell , cancer research , cancer , microbiology and biotechnology , biochemistry , biology , in vitro , genetics
The antiproliferative effects of various ferrocenyl olefins were evaluated against the cell lines MCF‐7 (human breast cancer cells), DLD‐1 (human colon adenocarcinoma cells), HUVEC (human umbilical vein endothelial cells), and A549 (human lung carcinoma cells), using the MTT test. IC 50 values were determined. Compounds 8 , 9 , 11 , and 12 with high antiproliferative activity were tested for their reactive oxygen species (ROS) production, and cell cycle analysis was performed on A549 cells. The results show that these compounds might perform their antiproliferative activity through inducing ROS generation, apoptosis induction, and cell cycle arrest.