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Synthesis, Biological, and Computational Evaluation of Novel 1,3,5‐Substituted Indolin‐2‐one Derivatives as Inhibitors of Src Tyrosine Kinase
Author(s) -
KilicKurt Zühal,
Bakar Filiz,
Ölgen Süreyya
Publication year - 2015
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201500109
Subject(s) - proto oncogene tyrosine protein kinase src , chemistry , docking (animal) , stereochemistry , hydrogen bond , indole test , ic50 , tyrosine kinase , combinatorial chemistry , kinase , molecular model , biochemistry , in vitro , molecule , organic chemistry , receptor , medicine , nursing
Several substituted indolin‐2‐one derivatives were synthesized and evaluated for their activities against Src kinase. Several compounds showed activity against Src, with IC 50 values in the low micromolar range. Among them, compound 2f showed the most significant activity with an IC 50 value of 1.02 μM. Molecular docking studies have been performed for evaluation of the binding modes of compound 2f into the Src active site. The docking structure of compound 2f disclosed that the indole NH forms a hydrogen bond with the carbonyl of Met341. These results suggest that our novel compound 2f is a promising compound for the further development of indole‐based drugs targeting Src kinase.