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Synthesis and Characterization of New 1,2,4‐Triazolo[1,5‐ a ]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti‐Inflammatory/Antioxidant Effects
Author(s) -
Mekheimer Ramadan A.,
Sayed Ahmed A. Radwan,
Ahmed Eltaib A.,
Sadek Kamal U.
Publication year - 2015
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201500069
Subject(s) - chemistry , carrageenan , antioxidant , life span , glycation , anti inflammatory , ring (chemistry) , stereochemistry , combinatorial chemistry , biochemistry , organic chemistry , pharmacology , biology , receptor , evolutionary biology
In the present study, we describe the synthesis of a new set of 1,2,4‐triazolo[1,5‐ a ]pyridines and their fused ring systems. The products were assayed for various types of biological activities like anti‐inflammatory and antioxidative activity. Compounds 4c , 4f , 12a , 14 , 16 , and 19 were found to reduce carrageenan‐ and dextran‐induced inflammation in rats. In addition, compounds 4f and 12a were found to have antioxidative radical scavenging activity. Furthermore, these compounds were tested in the model system Caenorhabiditis elegans and there increased heat stress resistance, reduced the formation of advanced glycation end products, and finally extended the life span.