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Acetylcholinesterase Inhibitory and Antioxidant Activities of Novel Symmetric Sulfamides Derived from Phenethylamines
Author(s) -
Aksu Kadir,
Topal Fevzi,
Gulcin İlhami,
Tümer Ferhan,
Göksu Süleyman
Publication year - 2015
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201500035
Subject(s) - chemistry , dpph , abts , antioxidant , phenethylamines , acetylcholinesterase , chelation , combinatorial chemistry , organic chemistry , stereochemistry , enzyme
The antioxidant and acetylcholinesterase inhibitory properties of novel symmetric sulfamides derived from phenethylamines were evaluated. Phenethylamines 8–11 were reacted with SO 2 Cl 2 in the presence of Et 3 N to afford sulfamides in good yields. The synthesized sulfamides were converted to their phenolic derivatives with BBr 3 . We elucidated the antioxidant activity of novel symmetric sulfamides by using different bioanalytical assays. For this purpose, the radical scavenging activities of the novel symmetric sulfamides were assessed by DPPH • , ABTS •+ , DMPD •+ , and O 2 •– radical scavenging tests. In addition, the reducing abilities of the novel symmetric sulfamides were evaluated by Fe 3+ ‐Fe 2+ reducing, Cu 2+ ‐Cu + reducing, and [Fe 3+ ‐(TPTZ) 2 ] 3+ ‐[Fe 2+ ‐(TPTZ) 2 ] 2+ reducing activity tests. Also, the Fe 2+ chelating activity by the pipyrdyl reagent and the acetylcholinesterase inhibitory activities of the novel symmetric sulfamides were studied. Especially, the novel phenolic and symmetric sulfamides 16–19 showed high antioxidant and acetylcholinesterase inhibitory properties. On the other hand, IC 50 values were calculated for the DPPH • , ABTS •+ , DMPD •+ , and O 2 •– scavenging, the metal chelating, and the acetylcholinesterase inhibition effects of the novel symmetric sulfamides.