Synthesis and Determination of Some Biological Activities of Novel 2,4‐Dinitrophenyl Derivatives | Zendy

Öztürk Sarikaya Sevim B. | Zendy; Kaya Afşin A. | Zendy; Kaya Elif Çelenk | Zendy; Şentürk Murat | Zendy

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Synthesis and Determination of Some Biological Activities of Novel 2,4‐Dinitrophenyl Derivatives

Author(s) -

Öztürk Sarikaya Sevim B.,

Kaya Afşin A.,

Kaya Elif Çelenk,

Şentürk Murat

Publication year - 2015

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.201400330

Subject(s) - chemistry , butylated hydroxyanisole , trolox , butylated hydroxytoluene , abts , antioxidant , ferrous , chelation , nuclear chemistry , ferric , organic chemistry , medicinal chemistry , dpph

The antioxidant and radical scavenging activities of the synthesized compounds 3 , 5 , and 6 were determined by various in vitro assays such as 2,2‐azino‐bis(3‐ethylbenzthiazoline‐6‐sulfonic acid radical (ABTS ·+ ) scavenging, ferric ion (Fe 3+ ) reducing power and ferrous ion (Fe 2+ ) chelating activities. Moreover, these activities were compared to those of standard antioxidants such as butylated hydroxyanisole, butylated hydroxytoluene, and trolox. The results showed that the new compounds ( 3 , 5 , and 6 ) had potential antioxidant activity. Besides, inhibition of the two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I and II with some nitrobenzene compounds was investigated. Compounds 1–6 showed K i values in the range of 4.88–193.4 µM and 5.295–54.75 µM for hCA I and hCA II, respectively.

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