Synthesis, Xanthine Oxidase Inhibition, and Antioxidant Screening of Benzophenone Tagged Thiazolidinone Analogs | Zendy

Lakshmi Ranganatha V. | Zendy; Begum A. Bushra | Zendy; Naveen P. | Zendy; Zameer Farhan | Zendy; Hegdekatte Raghavendra | Zendy; Khanum Shaukath Ara | Zendy

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Synthesis, Xanthine Oxidase Inhibition, and Antioxidant Screening of Benzophenone Tagged Thiazolidinone Analogs

Author(s) -

Lakshmi Ranganatha V.,

Begum A. Bushra,

Naveen P.,

Zameer Farhan,

Hegdekatte Raghavendra,

Khanum Shaukath Ara

Publication year - 2014

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.201400058

Subject(s) - chemistry , xanthine oxidase , antioxidant , thioglycolic acid , xanthine , stereochemistry , hydrazide , xanthine oxidase inhibitor , combinatorial chemistry , nuclear chemistry , organic chemistry , enzyme

A series of novel 2‐(diaryl methanone)‐ N ‐(4‐oxo‐2‐phenyl‐thiazolidin‐3‐yl)‐acetamides were synthesized by various Schiff bases of (4‐benzoyl‐phenoxy)‐aceto hydrazide with thioglycolic acid. The structures of the newly synthesized compounds were confirmed by IR, 1 H NMR, mass spectra, and C, H, N analysis. Further, all the synthesized compounds 9a – n were evaluated for xanthine oxidase (XO) inhibition and antioxidant properties. Among all the tested compounds, 9f , 9m , and 9n demonstrated potent XO inhibition of 52, 76, and 26%, respectively, compared to the standard drug allopurinol, which is evident from in vitro and in silico analysis. On the other hand, compounds 9c , 9d , and 9k exhibit potent antioxidant properties.

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