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Synthesis, Xanthine Oxidase Inhibition, and Antioxidant Screening of Benzophenone Tagged Thiazolidinone Analogs
Author(s) -
Lakshmi Ranganatha V.,
Begum A. Bushra,
Naveen P.,
Zameer Farhan,
Hegdekatte Raghavendra,
Khanum Shaukath Ara
Publication year - 2014
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201400058
Subject(s) - chemistry , xanthine oxidase , antioxidant , thioglycolic acid , xanthine , stereochemistry , hydrazide , xanthine oxidase inhibitor , combinatorial chemistry , nuclear chemistry , organic chemistry , enzyme
A series of novel 2‐(diaryl methanone)‐ N ‐(4‐oxo‐2‐phenyl‐thiazolidin‐3‐yl)‐acetamides were synthesized by various Schiff bases of (4‐benzoyl‐phenoxy)‐aceto hydrazide with thioglycolic acid. The structures of the newly synthesized compounds were confirmed by IR, 1 H NMR, mass spectra, and C, H, N analysis. Further, all the synthesized compounds 9a – n were evaluated for xanthine oxidase (XO) inhibition and antioxidant properties. Among all the tested compounds, 9f , 9m , and 9n demonstrated potent XO inhibition of 52, 76, and 26%, respectively, compared to the standard drug allopurinol, which is evident from in vitro and in silico analysis. On the other hand, compounds 9c , 9d , and 9k exhibit potent antioxidant properties.