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Synthesis of Some Novel 1,2,4‐Triazol‐3‐one Derivatives Bearing the Salicyl Moiety and Their Anticonvulsant Activities
Author(s) -
Kahveci Bahittin,
Menteşe Emre,
Akkaya Emre,
Yılmaz Fatih,
Doğan İnci S.,
Özel Arzu
Publication year - 2014
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201300427
Subject(s) - anticonvulsant , moiety , chemistry , microwave irradiation , stereochemistry , chemical synthesis , pharmacology , epilepsy , organic chemistry , biochemistry , psychology , medicine , catalysis , in vitro , neuroscience
A series of new 1,2,4‐triazole‐3‐one derivatives bearing the salicyl moiety were synthesized by using microwave irradiation, and their chemical structures were identified by IR, 1 H NMR, 13 C NMR, elemental analysis, and LC‐MS. The anticonvulsant activities of the compounds 4a – c , 4e , and 5a – e were evaluated by the Anticonvulsant Screening Program of the National Institute of Health, USA. The compounds had moderate anticonvulsant activities in the maximum electroshock‐induced seizure and minimal clonic seizure models in mice, without any neurotoxic effects.