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Antiproliferative and Antiviral Activity of Three Libraries of Adamantane Derivatives
Author(s) -
Basarić Nikola,
Sohora Margareta,
Cindro Nikola,
MlinarićMajerski Kata,
De Clercq Erik,
Balzarini Jan
Publication year - 2014
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201300345
Subject(s) - adamantane , hela , leukemia , chemistry , dna , cervix carcinoma , virology , biology , pharmacology , cervical carcinoma , in vitro , biochemistry , immunology , cancer , genetics , cervical cancer , organic chemistry
Three libraries of adamantane derivatives were synthesized and evaluated for antiviral and antiproliferative activities against a broad variety of DNA and RNA viruses. Whereas none of the compounds exhibit antiviral activity at subtoxic concentrations, antiproliferative activity was found against murine leukemia cells (L1210), human T‐lymphocyte cells (CEM), and cervix carcinoma cells (HeLa) for 4 , 8 , and 10 .