Premium
Synthesis, Antioxidant, and Xanthine Oxidase Inhibitory Activities of 5‐[4‐[2‐(5‐ E thyl‐2‐pyridinyl)ethoxy]phenyl]methyl]‐2,4‐thiazolidinedione Derivatives
Author(s) -
Begum A. Bushra,
Begum Muneera,
Ranganatha V. Lakshmi,
Prashanth T.,
Zameer Farhan,
Hegdekatte Raghavendra,
Khanum Shaukath Ara
Publication year - 2014
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201300319
Subject(s) - xanthine oxidase , chemistry , superoxide , antioxidant , reactive oxygen species , thiazolidinedione , oxidative stress , biochemistry , nitric oxide , pharmacology , stereochemistry , enzyme , organic chemistry , endocrinology , biology , type 2 diabetes , diabetes mellitus
Xanthine oxidase (XO) is a complex metalloflavoprotein, the overproduction of which usually leads to a pathological condition called gout. The XO inhibitors may prove to be promising antigout agents. The XO generates superoxide anions and H 2 O 2 for the self‐defense system of the organism. Abnormal production of this superoxide (reactive oxygen species) is responsible for a number of complications including inflammation, metabolic disorder, cellular aging, reperfusion damage, atherosclerosis, and carcinogenesis. In this paper, we report the synthesis of N ‐substituted analogs of thiazolidinedione derivatives as effective and new class of XO inhibitors and also as antioxidant agents. Among all the compounds in the series, compound 2i produced relatively better activity against human milk XO (72% inhibition), which was also supported by docking studies.