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Green Synthesis and Biological Evaluation of New Di‐α‐aminophosphonate Derivatives as Cytotoxic Agents
Author(s) -
Uma Maheswara Rao Kunda,
Namkoong Sim,
Yu HwanChul,
Park Junsoo,
Chung ChanMoon,
Oh Se Young
Publication year - 2013
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201300249
Subject(s) - chemistry , cytotoxic t cell , human breast , in vitro , cell culture , mtt assay , cytotoxicity , cancer cell lines , carbon 13 nmr , stereochemistry , combinatorial chemistry , cancer cell , biochemistry , cancer , biology , genetics
A series of novel di‐α‐aminophosphonate derivatives were synthesized by a one‐pot method in the presence of PEG–H 2 O under ultrasonic irradiation and were characterized by IR, 1 H NMR, 13 C NMR, mass spectrometry, and elemental analysis. The newly synthesized compounds were evaluated for their cytotoxic activities against the human lung cancer cell line H1299 and the human breast cancer cell line MCF7 in vitro by the MTT method. All compounds showed moderate cytotoxic activity on both cell lines, and compounds 4b and 4c showed marked activity.