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Green Synthesis of α‐ A minophosphonate Derivatives on a Solid Supported Ti O 2 – S i O 2 Catalyst and Their Anticancer Activity
Author(s) -
Chinthaparthi Radha Rani,
Bhatnagar Ira,
Gangireddy Chandra Sekhar Reddy,
Syama Sundar Chereddy,
Cirandur Suresh Reddy
Publication year - 2013
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201300214
Subject(s) - chemistry , catalysis , stereochemistry , organic chemistry
Syntheses of a new series of biologically potent α‐aminophosphonates were accomplished by one‐pot Kabachnik–Fields reaction using TiO 2 –SiO 2 as solid supported catalyst under microwave irradiation conditions. The chemical structures of all the newly synthesized compounds were confirmed by analytical and spectral (IR, 1 H, 13 C, 31 P NMR, and mass) data. Their anticancer nature was evaluated by screening the in vitro activity on two human cancer cell lines, HeLa and SK‐BR‐3. Compounds 4i and 4o showed the best activity on these cancer cells even though the majority of the compounds, and particularly 4l and 4p , have good cytotoxic activity against them.