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Facile Regioselective Synthesis of Novel bis ‐ T hiazole Derivatives and Their Antimicrobial Activity
Author(s) -
Mahmoodi Nosrat O.,
Parvizi Jafar,
Sharifzadeh Bahman,
Rassa Mehdi
Publication year - 2013
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201300187
Subject(s) - micrococcus luteus , bacillus subtilis , antimicrobial , pseudomonas aeruginosa , bacteria , chemistry , escherichia coli , gram positive bacteria , antibacterial activity , gram negative bacteria , regioselectivity , combinatorial chemistry , micrococcus , microbiology and biotechnology , stereochemistry , biochemistry , organic chemistry , biology , catalysis , genetics , gene
The design and synthesis of several new bis ‐thiazoles 4a – h serving as bis ‐drugs in comparison with mono ‐heterocyclic analogs are described. These bis ‐drugs present superior medicinal and pharmacological activities against both gram‐negative ( Pseudomonas aeruginosa and Escherichia coli ) and gram‐positive ( Micrococcus luteus and Bacillus subtilis ) bacteria, which are in general more sensitive to compounds with higher hydrophobicity. Compounds with higher hydrophobicity ( 4d and 4h ) exhibited some activity against the gram‐negative bacteria.