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Synthesis, Antibacterial, and Antiviral Evaluation of New Heterocycles Containing the Pyridine Moiety
Author(s) -
Salem Marwa S.,
Sakr Sameh I.,
ElSenousy Waled M.,
Madkour Hassan M. F.
Publication year - 2013
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201300183
Subject(s) - moiety , pyrazole , chemistry , nitrile , pyridine , antimicrobial , combinatorial chemistry , dihydropyridine , stereochemistry , chemical synthesis , antibacterial activity , organic chemistry , bacteria , in vitro , biochemistry , calcium , biology , genetics
A facile one‐pot four‐component reaction was utilized to construct 2‐oxo‐1,2‐dihydropyridine‐3‐carbonitrile as a scaffold for the synthesis of many fused heterocyclic systems, namely, furopyridine, pyridothiadiazepinthione, and pyridotriazine, as well as non‐fused heterocyclic systems such as phthalazin‐2(1 H )‐ylnicotinonitrile, pyridin‐2‐yl‐1 H ‐pyrazole, and pyrazol‐1‐ylnicotino‐nitrile,1‐(3‐cyanopyridin‐2‐yl)‐1 H ‐pyrazole. The new compounds were evaluated as antimicrobial and antiviral agents.