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Studies on Organophosphorus Compounds. Part 1: Synthesis and In Vitro Antimicrobial Activity of Some New Pyrimido[5′,4′:5,6]pyrano[2,3‐ d ][1,3,2]thiazaphosphinine Compounds
Author(s) -
Younes Sabry H. H.,
Mohamed Shaaban K.,
Albayati Mustafa R.
Publication year - 2013
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201300171
Subject(s) - chemistry , antimicrobial , reagent , acetonitrile , pyrimidine , in vitro , biological activity , combinatorial chemistry , elemental analysis , organic chemistry , stereochemistry , nuclear chemistry , biochemistry
2,4‐Bis(4‐methoxyphenyl)‐1,3,2,4‐dithiadiphosphetane‐2,4‐disulfide (Lawesson's reagent, LR) reacted with pyrano[2,3‐ d ]pyrimidine‐2,4‐(1 H ,3 H )‐dione derivatives in boiling acetonitrile to afford various pyrimido[5′,4′:5,6]pyrano[2,3‐ d ][1,3,2]thiazaphosphinine derivatives. The structures of the target compounds were characterized by elemental analysis and spectral data. The biological activities of all synthesized compounds were tested against various microorganisms by the disk diffusion method. In general, the newly synthesized compounds showed good inhibitory effects against most of the applied microorganisms.