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Synthesis of Some New Benzisothiazolone and Benzenesulfonamide Derivatives of Biological Interest Starting from Saccharin Sodium
Author(s) -
ElSabbagh Osama I.
Publication year - 2013
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201300110
Subject(s) - thiazole , chemistry , saccharin , sodium , sodium azide , biological activity , stereochemistry , strain (injury) , chemical synthesis , organic chemistry , in vitro , biology , biochemistry , endocrinology , anatomy
Two new series of benzenesulfonamide ( 4a – f , 5a – b , 6 , 7 ) and 1,2‐benzisothiazol‐3(2 H )‐one‐1,1‐dioxide ( 9a – c , 10 , 12a – d ) derivatives were prepared starting from saccharin sodium. The novel compounds were characterized using elemental analyses and different spectroscopic methods. Assessment of the antiviral activities of these novel compounds against a broad panel of viruses in different cell cultures revealed that only the thiazole derivatives belonging to the benzisothiazol‐3(2 H )‐one‐1,1‐dioxide series are the active ones. All thiazole derivatives 12a – d showed activity against both varicella‐zoster virus, especially TK − VZV strain 07‐1, and the cytomegalovirus strains AD‐169 and Davis in human embryonic lung (HEL) cell culture.