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Synthesis and Radical Scavenging Activities of Resveratrol Analogs
Author(s) -
Csuk René,
Albert Sabrina,
Siewert Bianka
Publication year - 2013
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201300081
Subject(s) - chemistry , resveratrol , scavenger , dpph , scavenging , free radical scavenger , antioxidant , biological activity , organic chemistry , stereochemistry , biochemistry , in vitro
Highly substituted polyhydroxylated ( E )‐stilbenes were synthesized by Mizoroki–Heck reactions and tested for their ability to act as radical scavenger. One of the 56 stilbenes included in this study and investigated in DPPH assays gave an SC 50 value of 11.0 μM, hence exhibiting an about 9.3 times higher activity than resveratrol. As shown in a photometric SRB assay using mouse NiH 3T3 fibroblasts, this compound is not cytotoxic up to concentrations of <30 μM.