Premium
Resveratrol Derived Butyrylcholinesterase Inhibitors
Author(s) -
Csuk René,
Albert Sabrina,
Kluge Ralph,
Ströhl Dieter
Publication year - 2013
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201300051
Subject(s) - butyrylcholinesterase , chemistry , acetylcholinesterase , cholinesterase , substituent , resveratrol , enzyme , biochemistry , stereochemistry , pharmacology , aché , biology
Novel polyhydroxylated ( E )‐stilbenes were synthesized by Mizoroki–Heck reactions and tested for their ability to inhibit the enzymes acetyl‐ and butyrylcholinesterase. Several of them are good inhibitors of butyrylcholinesterase; one of them carrying an extra fluorine substituent is a 94‐fold stronger inhibitor of butyrylcholinesterase than of acetylcholinesterase.