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Synthesis, In Vitro Antimicrobial and Antioxidant Activities of Some New 4,5‐Dihydro‐1 H ‐1,2,4‐triazol‐5‐one Derivatives
Author(s) -
Yüksek Haydar,
Akyıldırım Onur,
Yola Mehmet L.,
GürsoyKol Özlem,
Çelebier Mustafa,
Kart Didem
Publication year - 2013
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201300048
Subject(s) - chemistry , antimicrobial , methanol , antioxidant , in vitro , aqueous solution , high performance liquid chromatography , organic chemistry , chromatography , nuclear chemistry , biochemistry
A series of compounds derived from 4,5‐dihydro‐1 H ‐1,2,4‐triazol‐5‐one were synthesized and characterized by spectral data. The 12 new compounds were analyzed for their potential in vitro antioxidant activities by three different methods. Compound 4f showed the best activity for the iron binding. In addition, the compounds 4 were titrated potentiometrically with tetrabutylammonium hydroxide in non‐aqueous solvents. The RP‐HPLC capacity factors ( k ′) of the series were also determined on a C18 column, with methanol/water as the mobile phase. The correlation between log k ′ with the percentage of methanol in the mobile phase was used for the determination of the log k w values for these compounds. The antimicrobial activities of these compounds were also screened against bacteria and yeast.