Quinolinesulfonamides of Aryloxy‐/Arylthio‐ethyl Piperidines: Influence of an Arylether Fragment on 5‐HT 1A /5‐HT 7  Receptor Selectivity | Zendy

Grychowska Katarzyna | Zendy; Marciniec Krzysztof | Zendy; Canale Vittorio | Zendy; Szymiec Michał | Zendy; Glanowski Grzegorz | Zendy; Satała Grzegorz | Zendy; Maślankiewicz Andrzej | Zendy; Pawłowski Maciej | Zendy; Bojarski Andrzej J. | Zendy; Zajdel Paweł | Zendy

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Quinolinesulfonamides of Aryloxy‐/Arylthio‐ethyl Piperidines: Influence of an Arylether Fragment on 5‐HT 1A /5‐HT 7 Receptor Selectivity

Author(s) -

Grychowska Katarzyna,

Marciniec Krzysztof,

Canale Vittorio,

Szymiec Michał,

Glanowski Grzegorz,

Satała Grzegorz,

Maślankiewicz Andrzej,

Pawłowski Maciej,

Bojarski Andrzej J.,

Zajdel Paweł

Publication year - 2013

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.201200322

Subject(s) - chemistry , alicyclic compound , selectivity , quinoline , aryl , combinatorial chemistry , stereochemistry , chemical synthesis , receptor , organic chemistry , biochemistry , in vitro , alkyl , catalysis

The solid‐phase synthesis of a new series of 19 biomimetics of long‐chain arylpiperazines, namely flexible quinoline sulfonamides of aryl(heteroaryl)oxy‐/heteroarylthio‐ethyl 4‐aminomethylpiperidines, is reported. Various structural modifications applied followed by biological evaluation for 5‐HT 1A , 5‐HT 6 , and 5‐HT 7 receptors gave further support of a possible replacement of arylpiperazine with aryloxy‐/arylthio‐ethyl derivatives of alicyclic amines and control of receptor selectivity upon diversification in the aryl(heteroaryl)oxy‐/heteroarylthio‐ethyl fragment.

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