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Quinolinesulfonamides of Aryloxy‐/Arylthio‐ethyl Piperidines: Influence of an Arylether Fragment on 5‐HT 1A /5‐HT 7 Receptor Selectivity
Author(s) -
Grychowska Katarzyna,
Marciniec Krzysztof,
Canale Vittorio,
Szymiec Michał,
Glanowski Grzegorz,
Satała Grzegorz,
Maślankiewicz Andrzej,
Pawłowski Maciej,
Bojarski Andrzej J.,
Zajdel Paweł
Publication year - 2013
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201200322
Subject(s) - chemistry , alicyclic compound , selectivity , quinoline , aryl , combinatorial chemistry , stereochemistry , chemical synthesis , receptor , organic chemistry , biochemistry , in vitro , alkyl , catalysis
The solid‐phase synthesis of a new series of 19 biomimetics of long‐chain arylpiperazines, namely flexible quinoline sulfonamides of aryl(heteroaryl)oxy‐/heteroarylthio‐ethyl 4‐aminomethylpiperidines, is reported. Various structural modifications applied followed by biological evaluation for 5‐HT 1A , 5‐HT 6 , and 5‐HT 7 receptors gave further support of a possible replacement of arylpiperazine with aryloxy‐/arylthio‐ethyl derivatives of alicyclic amines and control of receptor selectivity upon diversification in the aryl(heteroaryl)oxy‐/heteroarylthio‐ethyl fragment.