Synthesis, Cytotoxicity, and Apoptosis Induction Study of Antitumor Dinuclear Platinum(II) Complexes | Zendy

Xu Gang | Zendy; Gou Shaohua | Zendy; Gao Chuanzhu | Zendy

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Synthesis, Cytotoxicity, and Apoptosis Induction Study of Antitumor Dinuclear Platinum(II) Complexes

Author(s) -

Xu Gang,

Gou Shaohua,

Gao Chuanzhu

Publication year - 2013

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.201200288

Subject(s) - cytotoxicity , oxaliplatin , chemistry , carboplatin , apoptosis , cell culture , stereochemistry , platinum , in vitro , ligand (biochemistry) , biochemistry , combinatorial chemistry , cisplatin , receptor , biology , chemotherapy , cancer , colorectal cancer , genetics , catalysis

Five novel dinuclear platinum(II) complexes with a new chiral ligand, 3‐(2‐amino‐cyclohexylamino)‐propionic acid (HP), were designed, prepared and spectrally characterized. The in vitro cytotoxicities of these compounds were evaluated against the HepG‐2, MCF‐7, A549, and HCT‐116 cell lines. The results indicated that all compounds showed cytotoxicity towards the HepG‐2 cell line. Particularly, complex X5 , which has SO 4 2−as a bridge, exhibited better cytotoxicity than carboplatin or oxaliplatin against all selected cell lines. Moreover, double dyeing flow cytometric resection indicated that the target compounds inhibited tumor cell growth by inducing apoptosis.

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