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Synthesis of α‐Hydroxyphosphonates and Their Antioxidant Properties
Author(s) -
Naidu Kalla Reddi Mohan,
Kumar Krishnammagari Suresh,
Arulselvan Palanisamy,
Reddy Chinnappareddy Bhupendra,
Lasekan Ola
Publication year - 2012
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201200192
Subject(s) - chemistry , antioxidant , lipid peroxidation , superoxide dismutase , aldehyde , radical , catalase , glutathione , biochemistry , organic chemistry , enzyme , catalysis
A series of α‐hydroxyphosphonates were synthesized from the reaction of aldehyde ( 1 ) with triethylphosphite ( 2 ) in the presence of oxone and evaluated for their antioxidant properties against lipid peroxidation, reduced glutathione, superoxide dismutase, and catalase. The majority of the compounds showed promising antioxidant activity. Diethyl anthracen‐9‐yl (hydroxy) methylphosphonate ( 3n ) is the most potent and biologically active compound against free radicals.