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Synthesis and Antimicrobial Activities of a Novel Series of Heterocyclic α‐Aminophosphonates
Author(s) -
AbdelMegeed Mohamed F.,
Badr Badr E.,
Azaam Mohamed M.,
ElHiti Gamal A.
Publication year - 2012
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201200109
Subject(s) - bacillus subtilis , antimicrobial , escherichia coli , candida albicans , chemistry , staphylococcus aureus , bacteria , antibacterial activity , minimum inhibitory concentration , stereochemistry , microbiology and biotechnology , combinatorial chemistry , organic chemistry , biochemistry , biology , genetics , gene
Two series of novel α‐aminophosphonates having heterocyclic moieties were synthesized in high yields. The structures of the newly synthesized compounds were confirmed by their elemental analyses, IR, 1 H NMR and MS spectral data. These compounds were screened for their antibacterial activities against Escherichia coli (NCIM2065) as a Gram‐negative bacterium, Bacillus subtilis (PC1219) and Staphylococcus aureus (ATCC25292) as Gram‐positive bacteria, and Candida albicans and Saccharomyces cerevisiae as fungi. The minimum inhibitory concentrations (MICs) of the synthesized compounds show high antibacterial and antifungal activities at low concentrations (10–1000 µg/mL). Furthermore, their lethal doses indicated that such compounds are safe for use as antimicrobial agents.