Premium
Synthesis, Antitumor, and Antibacterial Activity of Bis[4,5‐diarylimidazol‐2‐ylidene]methane Derivatives
Author(s) -
Liu Wukun,
Chen Xiaohua,
Gust Ronald
Publication year - 2012
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201100474
Subject(s) - chemistry , methylene , bromide , imidazole , growth inhibition , antibacterial activity , methane , cationic polymerization , cell growth , medicinal chemistry , bacteria , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , biology , genetics
Cationic [bis(1,3‐diethyl‐4,5‐diarylimidazol‐2‐ylidene)]Au(I) bromide complexes have demonstrated considerable potential as new antitumor agents. In order to investigate whether the gold is crucial for the antitumor activity, the imidazole ligands were connected by a methylene bridge. Biological evaluation revealed that bis[1,3‐diethyl‐4,5‐diarylimidazol‐2‐ylidene]methane compounds exhibited growth inhibition effects against mammary (MCF‐7 and MDA‐MB 231) and colon (HT‐29) carcinoma cell lines. In comparison with gold complexes, the methylene derivatives showed drastically reduced cell growth inhibitory properties. However, the growth of bacteria was significantly inhibited by bis[1,3‐diethyl‐4,5‐bis(4‐methoxyphenyl)imidazol‐2‐ylidene]methane dibromide ( 4 ) and opens a new application of this compound type.