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Reactions of N 3 ‐Substituted Amidrazones with cis ‐1,2‐Cyclohexanedicarboxylic Anhydride and Biological Activities of the Products
Author(s) -
ModzelewskaBanachiewicz Bozena,
Ucherek Marzena,
Zimecki Michał,
Kutkowska Jolanta,
Kaminska Teresa,
MorakMłodawska Beata,
Paprocka Renata,
Szulc Michał,
Lewandowski Grzegorz,
Marciniak Joanna,
BobkiewiczKozlowska Teresa
Publication year - 2012
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201100333
Subject(s) - isoindole , chemistry , elemental analysis , organic chemistry , combinatorial chemistry , medicinal chemistry , stereochemistry
A series of novel compounds were synthesized in reactions of N 3 ‐substituted amidrazones with cis ‐1,2‐cyclohexanedicarboxylic anhydride: linear, isoindole, and triazole derivatives. All new structures were confirmed by H 1 NMR and IR spectrometry as well as elemental analysis. Potential biological effects of new compounds were predicted with the Prediction of Activity Spectra for Substances (PASS) program. Antiviral, antibacterial, analgesic, and anti‐inflammatory activities were experimentally verified.