Premium
Ultrasound‐Assisted Synthesis of Novel α‐Aminophosphonates and Their Biological Activity
Author(s) -
Rasheed Syed,
Venkataramana Katla,
Chandrasekhar Kuruva,
Fareeda Gemmalamadugu,
Raju Chamarthi Naga
Publication year - 2012
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201100256
Subject(s) - chemistry , antifungal , ethanol , catalysis , antibacterial activity , amine gas treating , biological activity , chemical synthesis , organic chemistry , lewis acids and bases , combinatorial chemistry , bacteria , nuclear chemistry , biochemistry , in vitro , biology , genetics , medicine , dermatology
The synthesis of a series of novel α‐aminosubstituted phosphonates was accomplished by the reaction of various substituted aldehydes with an amine amlodipine (3‐ethyl 5‐methyl (±)2‐((2‐aminoethoxy)methyl)‐4‐(2‐chlorophenyl)‐6‐methyl‐1,4‐dihydropyridene‐3,5‐dicarboxylate) followed by diethylphosphite/dibutylphosphite in ethanol using SnCl 2 .2H 2 O as a Lewis acid catalyst, under conventional and ultrasonic irradiation. Their structures were established by analytical and spectral data. The title compounds showed good antibacterial, antifungal and antiviral activity depending on the nature of the bioactive groups at the α‐carbon.