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Synthesis and Biological Activity of Ethyl 2‐(substituted benzylthio)‐4‐(3′‐(ethoxycarbonyl)biphenyl‐4‐yl)‐6‐methyl‐1,4‐dihydropyrimidine‐5‐carboxylate Derivatives
Author(s) -
Maddila Suresh,
Jonnalagadda Sreekantha B.
Publication year - 2012
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201100133
Subject(s) - aspergillus flavus , chemistry , antibacterial activity , aspergillus fumigatus , candida albicans , antimicrobial , microbiology and biotechnology , escherichia coli , aspergillus niger , stereochemistry , organic chemistry , bacteria , biology , biochemistry , genetics , gene
In the present study, a new series of ethyl 2‐(substituted benzylthio)‐4‐(3′‐(ethoxycarbonyl)‐biphenyl‐4‐yl)‐6‐methyl‐1,4‐dihydropyrimidine‐5‐carboxylate derivatives was synthesized. The newly synthesized compounds were characterized by 1 H‐NMR, mass and C, H, N analyses. All newly synthesized compounds were screened for their antibacterial ( Escherichia coli , Staphylococcus aureus , Pseudomonas aeruginosa , Streptococcus pyogenes and Klebsiella pneumoniae ) and antifungal ( Aspergillus flavus , Aspergillus fumigatus , Candida albicans , Penicillium marneffei and Trichophyton mentagrophytes ) activity. The results revealed that all synthesized compounds have a significant biological activity against the tested microorganisms. Compounds 8a , 8b , 8c , 8e , 8f , 8i , and 8j exhibited good antimicrobial activity.