Premium
Mild Synthetic Approach to Novel Indole‐1‐Carbinols and Preliminary Evaluation of Their Cytotoxicity in Hepatocarcinoma Cells
Author(s) -
Zedda Gloria,
Simbula Gabriella,
Begala Michela,
Pibiri Monica,
Floris Costantino,
Casu Mariano,
Casu Laura,
Tocco Graziella
Publication year - 2012
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201100104
Subject(s) - paraformaldehyde , indole test , cytotoxicity , chemistry , solvent , combinatorial chemistry , chemical synthesis , organic chemistry , biochemistry , in vitro
A mild and versatile method for the synthesis of some novel indole‐1‐carbinols has been developed via one‐pot reaction of indoles and paraformaldehyde in the presence of an excess of CaO, MgO, ZnO or TiO 2 . The solvent‐free reaction provided all the indole derivatives in moderate to good yields and short reaction times. Moreover, the effect of some selected indole‐1‐carbinols on cell proliferation of the hepatoma cell line FaO was evaluated.