Premium
Synthesis and Cytotoxicity Evaluation of Novel Podophyllotoxin Derivatives
Author(s) -
Chengniu Wang,
Zhonghua Wu,
Yu Zhao,
Chunyan Ni,
Xiaodong Zhao,
Li Zhu
Publication year - 2011
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201100095
Subject(s) - podophyllotoxin , cytotoxicity , chemistry , stereochemistry , mtt assay , cancer cell lines , cell culture , chemical synthesis , chemical structure , cancer cell , combinatorial chemistry , cell growth , in vitro , cancer , biochemistry , organic chemistry , biology , genetics
Seven benzylamino derivatives of podophyllotoxin 8a–8g were synthesized and their chemical structures were confirmed by IR, 1 H‐NMR, 13 C‐NMR and ESI‐MS spectral analyses. Their abilities to inhibit the growth of cancer cells A549, HCT‐116 and HepG2, were investigated by MTT assay. Compound 8b possessed the highest cytotoxicity on cancer cell lines with average IC 50 values of 3.8 µM. All we synthetic compounds were cytotoxic against three cancer cell lines at the micromolar range, indicating podophyllotoxin derivatives with structural modification of benzylamino possess potent antitumor activity.