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Synthesis and Anticancer Activity of Indolin‐2‐one Derivatives Bearing the 4‐Thiazolidinone Moiety
Author(s) -
Wang Shuobing,
Zhao Yanfang,
Zhu Wufu,
Liu Ying,
Guo Kaixing,
Gong Ping
Publication year - 2012
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201100082
Subject(s) - moiety , cytotoxicity , chemistry , cell culture , stereochemistry , mtt assay , cancer cell lines , in vitro , selectivity , combinatorial chemistry , cancer cell , biochemistry , cancer , biology , genetics , catalysis
A novel series of indolin‐2‐one derivatives containing the 4‐thiazolidinone moiety ( 5a—5p ) was synthesized and the cytotoxicity of these derivatives was evaluated in vitro against three human cancer cell lines (HT‐29, H460 and MDA‐MB‐231) by standard MTT assay. Some prepared compounds exhibited significant cytotoxicity against different human cancer cell lines. Several potent compounds were further evaluated against one normal cell line (WI‐38). In particular, the promising compound 5h showed remarkable cytotoxicity and selectivity against the HT‐29 and H460 cancer cell lines (IC 50 = 0.016 µmol/L, 0.0037 µmol/L, respectively).