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Synthesis of New Pyrroles of Potential Anti‐Inflammatory Activity
Author(s) -
Mohamed Mosaad S.,
Kamel Rehab,
Fathallah Samar S.
Publication year - 2011
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201100056
Subject(s) - chemistry , ibuprofen , in vivo , pyrimidine , anti inflammatory , stereochemistry , structure–activity relationship , pyrrole , in vitro , combinatorial chemistry , biological activity , pharmacology , biochemistry , organic chemistry , biology , microbiology and biotechnology
We herein disclose a series of novel pyrrole derivatives 1–4 and pyrrolo[2,3‐ d ]pyrimidine derivatives 6–11 as novel potent anti‐inflammatory compounds. The structures were confirmed by IR, 1 H‐NMR, and MS. Some newly synthesized compounds were examined for their in‐vivo anti‐inflammatory activity. Several derivatives showed a promising anti‐inflammatory activity compared to ibuprofen. In this paper, we examine and discuss the structure–activity relationships and anti‐inflammatory activities of these compounds.