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Design, Synthesis and Antifungal Activity of Some New Imidazole and Triazole Derivatives
Author(s) -
Rezaei Zahra,
Khabnadideh Soghra,
Zomorodian Kamiar,
Pakshir Kyvan,
Kashi Giti,
Sanagoei Narges,
Gholami Sanaz
Publication year - 2011
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201000357
Subject(s) - candida tropicalis , candida glabrata , imidazole , chemistry , triazole , candida krusei , candida albicans , aspergillus flavus , microsporum canis , ketoconazole , stereochemistry , microbiology and biotechnology , organic chemistry , biology , antifungal , food science
Triazole and imidazole are incorporated into the structures of many antifungal compounds. In this study a novel series of 1,2,4‐triazole, imidazole, benzoimidazole, and benzotriazole derivatives was designed as inhibitors of cytochrome P450 14α‐demethylase (14DM). These structures were docked into the active site of MT‐CYP51, using Autodock program. Sixteen compounds with the best binding energy were synthesized. The chemical structures of the new compounds were confirmed by elemental and spectral ( 1 H‐NMR and Mass) analyses. All compounds were investigated for antifungal activity against Candida albicans , Candida tropicalis , Candida glabrata , Candida parapeilosis , Candida kruzei , Candida dubliniensis , Aspergillus fomigatus , Aspergillus flavus , Microsporum canis , Microsporum gypseum , Trichophyton mentagrophyte , Epidermophyton floccosum . Some compounds showed excellent in‐vitro antifungal activity against most of the tested fungi. Compounds 2 , 9 , and 10 had antifungal activity against several resistant fungi against fluconazole and itraconazole.