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Chemistry of Phosphorus Ylides. Part 33. Synthesis and Antitumor Activities of Some New Chromenone Derivatives
Author(s) -
Maigali Soher S.,
AbdElMaksoud Mansoura A.,
Soliman Fouad M.
Publication year - 2011
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201000341
Subject(s) - chemistry , cyclobutane , heteroatom , nucleophile , in vitro , stereochemistry , phosphorus , ring (chemistry) , biological activity , combinatorial chemistry , organic chemistry , biochemistry , catalysis
The reaction of nucleophilic phosphacumulene and phosphallene ylides with different chromenone derivatives was investigated. Heterocycles and carbocycles of various ring sizes and heteroatom patterns such as pyrano‐, oxaphosphino‐, cyclopenta‐, phosphoranylidene cyclobutane‐, and phospholo‐chromenones were obtained. The antitumor (breast and liver) properties of some new compounds were performed in vitro . Some of these compounds were more potent than the comparative standard.