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Synthesis and Biological Evaluation of Antifungal Activities of Novel 1,2‐ trans Glycosphingolipids
Author(s) -
Ding Ning,
Zhang Wei,
Lv Guokai,
Li Yingxia
Publication year - 2011
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201000335
Subject(s) - candida parapsilosis , candida tropicalis , antifungal , candida albicans , moiety , chemistry , in vitro , microbiology and biotechnology , biochemistry , biology , stereochemistry
Abstract The synthesis and in‐vitro biological evaluation of antifungal activities of a series of 1,2‐ trans glycosphingolipids (GSL) against Candida albicans , Candida parapsilosis , and Candida tropicalis were described. The preliminary study indicated that the sort of sugar moiety of GSLs affected their antifungal activities and selectivities towards the three Candida species, and the permeability might not be the sole parameter affecting their antifungal properties as presumed before, which would bring new clues to understand the antifungal profile for these types of compounds.