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Synthesis, Molecular Modelling and Biological Evaluation of 4‐Amino‐2(1 H )‐quinazolinone and 2,4(1 H ,3 H )‐Quinazolidone Derivatives as Antitumor Agents
Author(s) -
Richter Stephanie,
Gioffreda Barbara
Publication year - 2011
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201000312
Subject(s) - quinazolinone , chemistry , biological activity , stereochemistry , molecular model , combinatorial chemistry , chemical synthesis , pharmacology , biochemistry , in vitro , biology
A series of 6‐benzoyl‐, 6‐arylthio‐ and 6‐arylsulfonyl‐4‐amino‐2(1 H )‐quinazolinones and ‐2,4(1 H ,3 H )‐quinazolinediones were prepared. They were evaluated in vitro for their cytotoxicity against the NCI‐60 cancer cell lines.
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