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Synthesis and Anticancer Activity of 13‐Membered Cyclic Enediynes
Author(s) -
Sharma Mukul,
Joshi Mukesh C,
Kumar Vineet,
Malhotra Sanjay V.,
Rawat Diwan S.
Publication year - 2011
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201000309
Subject(s) - enediyne , melanoma , cancer research , cell culture , chemistry , stereochemistry , biology , genetics
We herein describe the synthesis of 15 novel 13‐membered cyclic enediyne derivatives using simple and straightforward approach. Representative examples were screened for their anticancer activities on 60 different human tumor cell lines representing various histologies viz. leukemia, melanoma, and cancers of lung, colon, kidney, ovary, breast, prostate, and central nervous system. The enediyne derivatives with halogen substitutions, especially fluorides were found to be active against most of the cell lines. The initial results indicates marginal to good inhibition for the growth of tumor cells for several cell lines, which shows the potential of these class of compound towards anticancer application.