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Synthesis and Antioxidant Activity of Substituted‐1,3,2‐Diazaphosphole 1‐Oxides
Author(s) -
Naidu Kalla Reddi Mohan,
Rao Pasupuleti Visweswara,
Raju Chamarthi Naga,
Srinivasulu Kambam
Publication year - 2011
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201000280
Subject(s) - triethylamine , chemistry , antioxidant , phenols , elemental analysis , oxide , chemical synthesis , organic chemistry , nuclear chemistry , in vitro , combinatorial chemistry , biochemistry
Synthesis of 1‐substituted‐1,3,2‐diazaphosphole 1‐oxides ( 3a–l ) were accomplished via a two‐step process. It involves the preparation of diazaphospholo 1‐oxide monochloride intermediate ( 2 ) and its subsequent reaction with phenols/amino acid esters in dry THF in the presence of triethylamine at 40–45°C. The structures of newly synthesized compounds were characterized by spectral and elemental analysis. The title compounds were evaluated for their in‐vitro antioxidant properties.