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Synthesis and Evaluation of Antibacterial Activities of 5,7‐Dihydroxycoumarin Derivatives
Author(s) -
Chin YiPing,
Huang WeiJan,
Hsu FengLin,
Lin YuhLing,
Lin MeiHsiang
Publication year - 2011
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201000233
Subject(s) - staphylococcus aureus , antibacterial activity , chemistry , microbiology and biotechnology , antibacterial agent , combinatorial chemistry , bacteria , biology , antibiotics , biochemistry , genetics
This study examines the synthesis and antibacterial activities of 5,7‐dihydroxycoumarin derivatives, whose structures were confirmed using analytical and spectral data. Twenty compounds were tested for their antibacterial activities against five microbial species such as E. coli , S. aureus , K. pneumonia , P. aeruginosa , and S. typhimurium were studied. Compounds 5 and 12 exhibited the most potent activity against Staphylococcus aureus with a MIC value of 2.5 µg/mL for each of the compounds.