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Synthesis and Anti‐ Candida Potential of Certain Novel 1‐[(3‐Substituted‐3‐phenyl)propyl]‐1 H ‐imidazoles
Author(s) -
AboulEnein Mohamed Nabil,
ElAzzouny Aida Abd ElSattar,
Attia Mohamed Ibrahim,
Saleh Ola Ahmed,
Kansoh Amany Lotfy
Publication year - 2011
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201000224
Subject(s) - chemistry , stereochemistry , combinatorial chemistry , medicinal chemistry
The synthesis and anti‐ Candida activity of 1‐[(3‐aroyloxy‐3‐phenyl)propyl]‐1 H ‐imidazoles 5a–f and 1‐[(3‐alkyl/aralkyl/phenyl‐3‐phenyl)propan‐3‐ol]‐1 H ‐imidazoles 5g–j are reported. The influence of the ester formation and different substitutions on the anti‐ Candida activity of the alcohol 4 was investigated. Among the newly developed bioactive chemical entities, compounds 5b and 5c displayed minimum inhibitory concentrations (MICs) against Candida albicans and Candida pseudotropicales comparable to that of tioconazole and more potent than miconazole.