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Synthesis of 4‐Hydroxycoumarin Heteroarylhybrids as Potential Antimicrobial Agents
Author(s) -
Siddiqui Zeba N.,
T. N. Mohammed Musthafa,
Ahmad Anis,
Khan Asad U.
Publication year - 2011
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201000218
Subject(s) - antimicrobial , klebsiella pneumonia , chemistry , aspergillus fumigatus , candida albicans , minimum inhibitory concentration , microbiology and biotechnology , staphylococcus aureus , pseudomonas aeruginosa , antibacterial activity , escherichia coli , bacteria , biology , organic chemistry , biochemistry , genetics , gene
Abstract A new series of 4‐hydroxycoumarin derivatives 3a–d was synthesized by the reaction of 3‐bromo‐4‐hydroxy coumarin 1 with various heteroaldehydes 2a–d in good yields. The synthesized compounds were characterized on the basis of their elemental and spectral (IR, 1 H‐NMR and mass spectrometry) analysis. All target compounds were evaluated for their in‐vitro antimicrobial activity against Streptococcus pyogenes , methicillin‐resistant Staphylococcus aureus , Pseudomonas aeruginosa , Klebsiella pneumonia , and Escherichia coli bacterial strains and fungal cultures of Candida albicans , Aspergillus fumigatus , Trichophyton mentagrophytes , and Penicillium marneffei by disk diffusion assay with slight modifications. The minimum inhibitory concentration (MIC) was determined for the test compounds as well as for reference standards. Among the tested compounds, 3a has shown the most potent antibacterial as well as antifungal activities.