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Platinum Complexes with 5‐Methyl‐5(4‐pyridyl)hydantoin and Its 3‐Methyl Derivatives: Synthesis and Cytotoxic Activity – Quantitative Structure‐Activity Relationships
Author(s) -
Bakalova Adriana,
Varbanov Hristo,
Buyukliev Rossen,
Momekov Georgi,
Ivanov Darvin,
Doytchinova Irini
Publication year - 2011
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201000182
Subject(s) - hydantoin , chemistry , platinum , molar conductivity , stereochemistry , medicinal chemistry , nmr spectra database , metal , organic chemistry , spectral line , catalysis , physics , astronomy
3,5‐Dimethyl‐5‐(4‐pyridyl)hydantoin (L) and its platinum(II) and platinum(IV) complexes with the general formula cis ‐[PtL 2 X 2 ] · n H 2 O and [PtL 2 Cl 4 ], where XCl, I and n = 2‐4 were synthesized. A new Pt(IV) complex with 5‐methyl‐5‐(4‐pyridyl)hydantoin (L′) with the formula cis ‐[Pt(L′) 2 Cl 2 (OH) 2 ] · 5 H 2 O was also synthesized. The novel compounds were characterized by elemental analysis, IR, 1 H‐, 13 C‐, 195 Pt‐NMR spectra and molar conductivity. The cytotoxic effects of these complexes were examined on three human tumor cell lines by MTT‐dye reduction assay. These four new Pt(II) and Pt(IV) complexes and a set of another twelve Pt(II), Pt(IV), and Pd(II) complexes previously synthesized and tested were compiled and a QSAR model was derived in order to direct the further rational synthesis.