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Antimicrobial Activity of a New Combination System of Benzimidazole and Various Azoles
Author(s) -
Özkay Yusuf,
Tunalı Yağmur,
Karaca Hülya,
Işıkdağ İlhan
Publication year - 2011
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201000172
Subject(s) - antimicrobial , benzimidazole , chemistry , brine shrimp , antifungal , toxicity , combinatorial chemistry , biological activity , stereochemistry , organic chemistry , microbiology and biotechnology , biochemistry , traditional medicine , in vitro , biology , medicine
In the present study a new series of benzimidazole derivatives bearing various (benz)azolylthio moieties were synthesized so as to investigate their antimicrobial activity. Structures of the target compounds ( 5a–5i ) were confirmed by their IR, 1 H‐NMR, ES‐MS spectral data, and elemental analyses. The synthesized compounds ( 5a–5i ) exhibited poor activity against bacterial strains. On the other hand, antifungal activity of the compounds against Candida species was very significant. Brine‐Shrimp lethality assay was performed for determination of toxicity of the compounds. Compounds 5a , 5c , and 5d were evaluated as non‐toxic in addition to their attractive antifungal activity. However, the other compounds ( 5b , e–i ) in the series showed toxicity to different extents.