Premium
Anti‐inflammatory, Analgesic, Anticonvulsant and Antiparkinsonian Activities of Some Pyridine Derivatives Using 2,6‐Disubstituted Isonicotinic Acid Hydrazides
Author(s) -
AlOmar Mohamed A.,
Amr Abd ElGalil E.,
AlSalahi Rashad A.
Publication year - 2010
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201000088
Subject(s) - chemistry , analgesic , anticonvulsant , isonicotinic acid , pyridine , chemical synthesis , pharmacology , stereochemistry , organic chemistry , epilepsy , biochemistry , hydrazide , medicine , neuroscience , in vitro , biology
A series of novel thiazolo derivatives 2–15 was synthesized by initial condensation of 2,6‐dihydroxyisonicotinohydrazide 1 and 2‐chloro‐6‐hydrazinylisonicotinohydrazide 11 with different organic reagents. The pharmacological screening showed that many of these obtained compounds have good anti‐inflammatory, analgesic, anticonvulsant, and antiparkinsonian activities comparable to diclofenac potassium, Voltarene®, Carbamazepine®, and Benzotropene® as reference drugs. Initially the acute toxicity of the compounds was assayed via the determination of their LD 50 . The structures of newly synthesized compounds were confirmed by IR, 1 H‐NMR, 13 C‐NMR, MS spectral data and elemental analysis. The detailed synthesis, spectroscopic data, LD 50 and pharmacological activities of the synthesized compounds were reported.