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Synthesis and in‐vitro Anti‐hepatitis B Virus Activity of Ethyl 6‐Bromo‐8‐hydroxyimidazo[1,2‐ a ]pyridine‐3‐carboxylates
Author(s) -
Chen Dong,
Liu Yajing,
Zhang Shulan,
Guo Dexiang,
Liu Chunhong,
Li Sai,
Gong Ping
Publication year - 2011
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201000045
Subject(s) - cytotoxicity , chemistry , pyridine , hepatitis b virus , in vitro , stereochemistry , virus , medicinal chemistry , virology , biochemistry , biology
A series of ethyl 6‐bromo‐8‐hydroxyimidazo[1,2‐ a ]pyridine‐3‐carboxylate derivatives were synthesized and evaluated for their anti‐hepatitis B virus (HBV) activity and cytotoxicity in HepG2.2.15 cells. Nearly half of the tested compounds were proved to be highly effective in inhibiting the replication of HBV DNA with IC 50 values ranging from 1.3 to 9.1 µM. Among them, 10o and 10s were identified as the most promising compounds.